Objective: This study aimed to understand the herpes simplex virus-2 (HSV-2) infection and related factors among female drug abusers in the women's compulsory drug rehabilitation center of Shandong province and to provide reference for the prevention and control of HSV-2 in these settings. Methods: We screened all of 451 female drug abusers in the women's compulsory drug rehabilitation centers in of Shandong province and conducted a study using both questionnaire investigation and serological tests for HSV-2, HIV and syphilis. We also used EpiData 3.1 software to establish a database and SPSS 20.0 software to conduct the χ(2) test and multivariate logistic regression analysis. Results: A total of 451 female drug abusers were under study. We noticed that the rates for HSV-2 infection, HIV infection and syphilis infection appeared as 72.1% (325/451), 2.2% (10/451) and 33.5% (151/451) respectively. Results from univariate analysis showed that factors as: awareness on AIDS, having temporary sex partner after using the drug, having multiple sex partners after using the drug, providing commercial services or having temporary sex practice before being detained, with syphilis infection etc., were associated with HSV-2 infection. Data from the multivariate analysis showed that the OR (95%CI) value of HSV-2 infection was 2.90 (1.19-7.06) for those who providing commercial service, when comparing to those who did not. Compared to those who did not suffer from syphilis infection, the OR (95%CI) value of HSV-2 infection for those with syphilis infection was 2.75 (1.63-4.63). Conclusions: The rate of HSV-2 infection was high in the women's compulsory drug rehabilitation center of Shandong province. We should enhance measures and promote condom use to prevent from HSV-2 and other sexually transmitted diseases among them.
目的： 了解山东省女子强制隔离戒毒所（山东女子强戒所）女性吸毒者Ⅱ型单纯疱疹病毒（HSV-2）感染情况及其相关因素，为HSV-2的有效防控工作提供参考依据。 方法： 对山东女子强戒所全体451名女性吸毒者进行筛查，开展问卷调查并进行HSV-2、HIV和梅毒血清学检测。采用EpiData 3.1软件建立数据库，SPSS 20.0软件进行χ(2)检验和多因素logistic回归分析。 结果： 共调查女性吸毒者451人，HSV-2感染率为72.1%（325/451），HIV感染率为2.2%（10/451），梅毒感染率为33.5%（151/451）。单因素分析显示，知晓艾滋病知识、使用毒品后的主要性伴是临时性伴、使用毒品后曾同时与多人发生过性行为、入所前曾提供过商业性服务、入所前曾发生过临时性行为、感染梅毒与HSV-2的感染相关。多因素分析显示，与未提供商业性服务者相比，提供过商业性服务者感染HSV-2的OR值（95%CI）为2.90（1.19~7.06）；与未感染梅毒者相比，感染梅毒者感染HSV-2的OR值（95%CI）为2.75（1.63~4.63）。 结论： 山东省女性强戒吸毒者HSV-2感染率较高，应加强HSV-2防治措施，推广使用安全套预防性传播疾病。.
Keywords: Female drug users; Herpes simplex virus-2; Related factors.