Abstract
We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by this antibiotic.
Keywords:
Wistar rats; gentamicin; glomerular basal membrane; α-tocopherol.
MeSH terms
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Acute Kidney Injury / chemically induced
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Acute Kidney Injury / metabolism
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Acute Kidney Injury / pathology
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Acute Kidney Injury / prevention & control*
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Animals
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Antioxidants / pharmacology*
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Catalase / blood
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Gentamicins / toxicity
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Kidney Glomerulus / drug effects
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Kidney Glomerulus / metabolism
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Kidney Glomerulus / pathology
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Kidney Tubules / drug effects
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Kidney Tubules / metabolism
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Kidney Tubules / pathology
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Malondialdehyde / blood
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Oxidative Stress / drug effects
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Rats
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Rats, Wistar
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alpha-Tocopherol / pharmacology*
Substances
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Antioxidants
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Gentamicins
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Malondialdehyde
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Catalase
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alpha-Tocopherol