The studies reported here are part of a series of experiments designed to characterize connective tissue cell response to sepiolite (magnesium silicate)-collagen complexes. The process of cell migration from skin explants to these complexes, normal and glutaraldehyde-treated, is similar to the control. The relative outgrowth value for both types of complex is 1.02 and 0.90 respectively, thus indicating a normal cell outgrowth.