In this study, adhesion, spreading, and attachment of human fibroblasts on collagen-sepiolite complexes have been studied. The behavior of the cultured cells has been compared to that of fibroblasts cultured on plastic dishes and collagen-coated dishes. This has been considered by studying the time course of the cell attachment and scanning electron microscopic observation of the events occurring during this process. The results obtained allow the conclusion that the collagen-sepiolite complexes are adhesive for cells.