[Levomepromazine as adjuvant sedation in a pediatric intensive care unit]

Vertex. 2017 Nov;28(136):411-415.
[Article in Spanish]

Abstract

Introduction: Sedation of patients in pediatric ICU extubated and in weaning of mechanic ventilation is diffcult under regular sedation, because of the tolerance and/or abstinence generated by its sustained use. The objective of this study is to describe the use of Levomepromazine as sedative coadjuvant in these patients.

Population and methods: Observational and longitudinal study in intensive care from Juan P. Garrahan Pediatric Hospital. Patients older than 2 years were included, extubated and in weaning of mechanic ventilation with requirements of additional sedation. The level of basal sedation and post-intervention (levomepromazine 0.5 mg/kg every 8 hours) were evaluated with Ramsay and Khalil scales. Doses of regular sedatives were compared before and after the indication. It was considered positive an increase of 1 in the scales, or a decrease of 20% in the regular sedatives doses.

Results: 36 patients, medium age of 8,5 years, average doses of levomepromazine 0.38 mg/kg. 97% showed positive result. The regular sedative doses were reduced more than 20% after the intervention. No adverse effects or deceased were registered.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Humans
  • Hypnotics and Sedatives / therapeutic use*
  • Intensive Care Units, Pediatric
  • Methotrimeprazine / therapeutic use*

Substances

  • Hypnotics and Sedatives
  • Methotrimeprazine