Partial defect in hepatic glutathione S-transferase activity in a case of Rotor's syndrome

Gastroenterol Jpn. 1987 Feb;22(1):34-8. doi: 10.1007/BF02806332.

Abstract

In a 17 year-old male patient with Rotor's syndrome, hepatic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene reduced to about 0.2% of the mean activity of patients with other diseases. The activities toward sulfobromophthalein and 1,2-dichloro-4-nitrobenzene were low (44% and 47%, respectively, of those controls), but basically present. Bilirubin UDP-glucuronyltransferase activity in this Rotor's syndrome case was in the normal range.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cholelithiasis / enzymology
  • Dinitrochlorobenzene
  • Glucosyltransferases / metabolism
  • Glucuronosyltransferase
  • Glutathione Transferase / genetics
  • Glutathione Transferase / metabolism*
  • Humans
  • Hyperbilirubinemia, Hereditary / enzymology*
  • Hyperbilirubinemia, Hereditary / genetics
  • Infant
  • Liver / enzymology*
  • Male
  • Middle Aged
  • Nitrobenzenes
  • Substrate Specificity
  • Sulfobromophthalein

Substances

  • Dinitrochlorobenzene
  • Nitrobenzenes
  • Sulfobromophthalein
  • 1,2-dichloro-4-nitrobenzene
  • Glucosyltransferases
  • bilirubin UDP-glucosyltransferase
  • Glucuronosyltransferase
  • Glutathione Transferase