CeO2 nanoparticles attenuate airway mucus secretion induced by TiO2 nanoparticles

Shih-Ming Tsai; Edith Duran-Robles; Tyler Goshia; Maria Mesina; Carlos Garcia; Julia Young; Angelo Sibal; Meng-Hsuen Chiu; Wei-Chun Chin

doi:10.1016/j.scitotenv.2018.03.001

CeO₂ nanoparticles attenuate airway mucus secretion induced by TiO₂ nanoparticles

Sci Total Environ. 2018 Aug 1:631-632:262-269. doi: 10.1016/j.scitotenv.2018.03.001. Epub 2018 Mar 16.

Authors

Shih-Ming Tsai¹, Edith Duran-Robles², Tyler Goshia³, Maria Mesina⁴, Carlos Garcia⁵, Julia Young⁶, Angelo Sibal⁷, Meng-Hsuen Chiu⁸, Wei-Chun Chin⁹

Affiliations

¹ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
² Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA.
³ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
⁴ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
⁵ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
⁶ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
⁷ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
⁸ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].
⁹ Bioengineering Program, School of Engineering, University of California at Merced, Merced, CA 95343, USA. Electronic address: [email protected].

Abstract

Nanotoxicity studies associated with various nanoparticles (NPs) have attracted intense research interest due to the broader applications of nanoparticles in our daily lives. The exposure of nanoparticles can lead to hypersecretion and accumulation of airway mucus which are closely associated with many respiratory diseases. Titanium dioxide (TiO₂), one of the PM10 components, is a major NP that is widely utilized in many commercial products. Our previous study established the connection between induced airway mucus secretion and TiO₂ NPs. However, the countermeasure to reduce the harmful effects of TiO₂ NPs, especially airway mucus secretion, remains unexplored. One of the potential candidates to reduce airway mucus secretion is cerium oxide (CeO₂) NPs. It has been reported that CeO₂ NPs can protect cells by diminishing ROS and inflammatory responses. Herein, our study shows that CeO₂ NPs are able to reduce cytosolic Ca²⁺ changes and mitochondrial damage caused by TiO₂ NPs. Our results provide the evidence that hypersecretion of mucus and apoptosis progression induced by TiO₂ NPs can be attenuated by CeO₂ NPs. This study highlights the potential capacity of CeO₂ NPs as a supplementary material for TiO₂ NPs applications in the future.

Keywords: BEAS-2B cell; Ca(2+) signaling; Nanoparticles.

MeSH terms

Cerium / metabolism*
Humans
Metal Nanoparticles / toxicity*
Protective Agents / metabolism*
Respiratory System / drug effects*
Respiratory System / metabolism
Titanium / toxicity*

Substances

Protective Agents
titanium dioxide
Cerium
ceric oxide
Titanium

Grants and funding

R15 HL095039/HL/NHLBI NIH HHS/United States