[Induced drug uveitis and drug side effects in ophthalmology]

Rev Med Interne. 2018 Sep;39(9):699-710. doi: 10.1016/j.revmed.2018.02.017. Epub 2018 Mar 9.
[Article in French]

Abstract

Ocular drug side effects are very varied and can affect all the structures of the eye. The purpose of this review is to help clinicians: (i) to evoke this drug-induced toxicity yearly in the course of an unexplained ocular injury, before its damage become irreversible, (ii) to be able to recognize induced paradoxical ocular inflammation, mimicking an inflammatory pathology flare-up, especially in patient under anti-TNF regimen and (iii) to propose a more in-depth knowledge on recently described ocular toxicities from targeted cancer therapy, mainly the tyrosine kinase inhibitors.

Keywords: Anti-TNF; Cornea; Cornée; Drug-induced; Effets secondaires; Iatrogénie; Inhibiteurs des tyrosines kinases; Kerathopathy; Keratitis; Kératite; Kératopathies; Névrite optique; Ocular; Optic neuritis; Retinopathy; Rétinopathie; Side effects; Toxicity; Toxicité oculaire; Tyrosine kinase inhibitors; Uveitis; Uvéites.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Diagnostic Techniques, Ophthalmological* / standards
  • Drug-Related Side Effects and Adverse Reactions / complications
  • Drug-Related Side Effects and Adverse Reactions / diagnosis*
  • Drug-Related Side Effects and Adverse Reactions / epidemiology
  • Drug-Related Side Effects and Adverse Reactions / therapy
  • Humans
  • Iatrogenic Disease
  • Ophthalmology / methods
  • Uveitis / chemically induced*
  • Uveitis / diagnosis*
  • Uveitis / epidemiology
  • Uveitis / therapy