Identification and characterization of two novel Gammapapillomavirus genomes in skin of an immunosuppressed Epidermodysplasia Verruciformis patient

Virus Res. 2018 Apr 2:249:66-68. doi: 10.1016/j.virusres.2018.03.003. Epub 2018 Mar 8.

Abstract

Two novel human gamma-papillomavirus genomes (HPV_MTS3, and HPV_MTS4) were isolated from the skin of an immunosuppressed, late-onset Epidermodysplasia Verruciformis patient and fully cloned. The L1 open reading frames of HPV_MTS3 and HPV_MTS4 were 77% and 91% identical to their closest HPV full genome isolates w18c39 and EV03c60, which belong to the species gamma-22and gamma-7 of the genus Gammapapillomavirus, respectively.

Keywords: Epidermodysplasia Verruciformis; Human; Immunosuppression; New gamma-HPV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsid Proteins / genetics
  • Epidermodysplasia Verruciformis / virology*
  • Gammapapillomavirus / classification*
  • Gammapapillomavirus / genetics
  • Gammapapillomavirus / isolation & purification*
  • Genome, Viral
  • Humans
  • Immunocompromised Host
  • Phylogeny
  • Sequence Analysis, DNA
  • Sequence Homology
  • Skin / virology*

Substances

  • Capsid Proteins