Langerhans cell histiocytosis mimicking molluscum contagiosum: A case series

Pediatr Blood Cancer. 2018 Jul;65(7):e27047. doi: 10.1002/pbc.27047. Epub 2018 Mar 12.

Abstract

Langerhans cell histiocytosis (LCH) is a disorder characterized by accumulation of Langerhans-like cells in one or various organs. A correct staging work-up is essential since there are multiorgan presentations with a poor prognosis. We report three patients with LCH skin lesions mimicking molluscum contagiosum in association with both high and low risk organ involvement. This peculiar cutaneous presentation can be a clue for the diagnosis of LCH, a disease with potentially severe systemic involvement.

Keywords: Langerhans cell histiocytosis; molluscum contagiosum; multisystem disease; skin.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Histiocytosis, Langerhans-Cell / diagnosis*
  • Histiocytosis, Langerhans-Cell / pathology*
  • Humans
  • Infant
  • Male
  • Molluscum Contagiosum / diagnosis*
  • Molluscum Contagiosum / pathology
  • Skin Diseases / diagnosis*
  • Skin Diseases / etiology
  • Skin Diseases / pathology
  • Young Adult