Templating Antiviral RNAi in Insects

Cell Host Microbe. 2018 Mar 14;23(3):290-292. doi: 10.1016/j.chom.2018.02.010.

Abstract

Virus-specific small interfering RNAs (siRNAs) are a central component of antiviral responses in insects. In this issue of Cell Host & Microbe, Poirier et al. (2018) demonstrate that virus-infected flies and mosquitoes produce virus-derived extrachromosomal circular DNAs that serve as a template for the biogenesis of antiviral siRNAs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antiviral Agents
  • Humans
  • Insecta
  • RNA Interference*
  • RNA, Small Interfering*
  • Viruses / genetics

Substances

  • Antiviral Agents
  • RNA, Small Interfering