Recruitment of thermogenic adipocytes within white fat depots represents a promising strategy to increase energy expenditure. Negative energy balance has been reported to promote adipose tissue browning in rodents. In a recent issue of Cell Reports, Barquissau et al. show that caloric restriction-associated weight loss does not induce browning of subcutaneous abdominal white fat in obese humans.
Keywords: adipocyte browning; caloric restriction; energy expenditure; free fatty acid flux; weight loss.
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