The article considers analysis and generalization of experience of the Nijegorodskaia oblast concerning development and implementation of effective management models of informational support of health care that can become a basis for structural and functional transformations in other regions of Russia. The proposed logistic concept is an effective tool of designing, modernization and development of system of informational support of regional health care that is proved by its successful application for resolving tasks of various scale and complicacy, including successful achievement of target indices of regional program of modernization of the Nijegorodskaia oblast.