Genetic Characterization of Enterovirus A71 Circulating in Africa

Maria Dolores Fernandez-Garcia; Romain Volle; Marie-Line Joffret; Serge Alain Sadeuh-Mba; Ionela Gouandjika-Vasilache; Ousmane Kebe; Michael R Wiley; Manasi Majumdar; Etienne Simon-Loriere; Anavaj Sakuntabhai; Gustavo Palacios; Javier Martin; Francis Delpeyroux; Kader Ndiaye; Maël Bessaud

doi:10.3201/eid2404.171783

Genetic Characterization of Enterovirus A71 Circulating in Africa

Emerg Infect Dis. 2018 Apr;24(4):754-757. doi: 10.3201/eid2404.171783.

Authors

Maria Dolores Fernandez-Garcia, Romain Volle, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Ionela Gouandjika-Vasilache, Ousmane Kebe, Michael R Wiley, Manasi Majumdar, Etienne Simon-Loriere, Anavaj Sakuntabhai, Gustavo Palacios, Javier Martin, Francis Delpeyroux, Kader Ndiaye, Maël Bessaud

Abstract

We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.

Keywords: Africa; acute flaccid paralysis; enterovirus; enterovirus A71; phylogenetic analysis; recombination; viruses; whole-genome analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enterovirus A, Human / classification*
Enterovirus A, Human / genetics*
Enterovirus Infections / epidemiology*
Enterovirus Infections / virology*
Genetic Variation
Genome, Viral
Genotype
Humans
Phylogeny
Recombination, Genetic