Paradoxical immune reconstitution inflammatory syndrome associated with disseminated tuberculosis infection in an unrelated donor cord blood transplant recipient

Transpl Infect Dis. 2018 Jun;20(3):e12889. doi: 10.1111/tid.12889. Epub 2018 Apr 3.

Abstract

Tuberculosis (TB) is an infrequent infection after hematopoietic cell transplant (HCT), with associated mortality up to 30%. The utility of universal screening for latent TB in HCT candidates is controversial due to the lack of sensitive screening tests. We describe a case of disseminated TB infection complicated by immune reconstitution inflammatory syndrome in an adult double unit umbilical cord blood transplant recipient who originated from the United Arab Emirates.

Keywords: hematopoietic cell transplant; immune reconstitution inflammatory syndrome; tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antitubercular Agents / therapeutic use
  • Diabetes Complications / microbiology
  • Diabetes Mellitus / microbiology
  • Fetal Blood / microbiology*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immune Reconstitution Inflammatory Syndrome / diagnosis
  • Immune Reconstitution Inflammatory Syndrome / etiology
  • Immune Reconstitution Inflammatory Syndrome / microbiology*
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / microbiology
  • Male
  • Transplant Recipients*
  • Treatment Outcome
  • Tuberculosis / blood
  • Tuberculosis / diagnosis*
  • Tuberculosis / etiology
  • Tuberculosis / transmission*
  • Unrelated Donors

Substances

  • Antitubercular Agents