Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung

Daniel C Wiener; Carlos E Bravo-Iñiguez; Vincent Trien-Vihn Ho; Xiaohua Qian; Michael T Jaklitsch

doi:10.1016/j.athoracsur.2017.11.002

Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung

Ann Thorac Surg. 2018 Apr;105(4):e145-e147. doi: 10.1016/j.athoracsur.2017.11.002.

Authors

Daniel C Wiener¹, Carlos E Bravo-Iñiguez², Vincent Trien-Vihn Ho³, Xiaohua Qian⁴, Michael T Jaklitsch²

Affiliations

¹ Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: [email protected].
² Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
³ Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts.
⁴ Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

PMID: 29571344
DOI: 10.1016/j.athoracsur.2017.11.002

Abstract

Donor T cells after allogeneic hematopoietic cell transplantation can give rise to the graft-versus-tumor (GVT) effect in hematologic malignancies. GVT effect has been reported previously to cause regression of some solid tumors. However, none have reported a documented case of GVT effect leading to complete resolution of adenocarcinoma of the lung. Here, we present the case of complete regression of a pathologically proven adenocarcinoma of the lung in a patient undergoing myeloablative-matched unrelated donor peripheral blood stem cell transplantation for the treatment of acute myelogenous leukemia.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / pathology*
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia, Myeloid, Acute / therapy*
Lung Neoplasms / pathology*
Male
Middle Aged
Remission Induction