Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China

Antimicrob Agents Chemother. 2018 May 25;62(6):e00153-18. doi: 10.1128/AAC.00153-18. Print 2018 Jun.

Abstract

Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

Keywords: Candida glabrata sensu stricto; MSH2; PDR1; antifungal resistance.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / pharmacology*
  • Candida glabrata / drug effects*
  • Candida glabrata / genetics*
  • Candida glabrata / isolation & purification
  • Candidemia / drug therapy
  • Candidemia / microbiology
  • Child
  • Child, Preschool
  • China
  • DNA-Binding Proteins / genetics
  • Drug Resistance, Multiple, Fungal / genetics*
  • Echinocandins / pharmacology*
  • Female
  • Fluconazole / pharmacology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Multilocus Sequence Typing
  • MutS Homolog 2 Protein / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Transcription Factors / genetics*
  • Young Adult

Substances

  • Antifungal Agents
  • DNA-Binding Proteins
  • Echinocandins
  • Transcription Factors
  • Fluconazole
  • MutS Homolog 2 Protein