Background: The ultrasound assisted synthesis and anti-bacterial evaluation of a series of compounds based on 1,2-disubstituted benzimidazole framework is reported here. The approach leading to the synthesis of these compounds involved the Cu-catalyzed coupling-cyclization of N-substituted 2-iodoanilines with benzamide derivatives in the presence of 2-aminoethanol as a ligand.
Conclusion: A number of compounds were prepared using this methodology in acceptable yield. Two of these compounds showed promising antibacterial activities when tested against both Gram-positive and Gram-negative bacterial strains.
Keywords: Benzimidazole; Cu-catalyzed; Gram-negative; Gram-positive; antibacterial; catalyst; ultrasound..
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