Abstract
A nude mouse system where the biological, morphological and biochemical characteristics of human endometrial carcinoma are maintained during serial transplantation has been previously described. Applications of this system to the study of (a) hormonal sensitivity (b) treatment strategies and (c) progesterone receptor physiology of human endometrial carcinomas are presented here.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use
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Carcinoma / drug therapy
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Carcinoma / metabolism*
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Carcinoma / pathology
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Cell Differentiation
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Estradiol / pharmacology
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Female
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Medroxyprogesterone / administration & dosage
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Medroxyprogesterone / analogs & derivatives
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Medroxyprogesterone / pharmacology
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Medroxyprogesterone Acetate
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Mice
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Mice, Nude*
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Neoplasm Transplantation
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Neoplasms, Hormone-Dependent / metabolism*
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Neoplasms, Hormone-Dependent / pathology
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Receptors, Estrogen / metabolism
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Receptors, Progesterone / metabolism*
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Tamoxifen / administration & dosage
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Tamoxifen / pharmacology
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Transplantation, Heterologous
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Uterine Neoplasms / drug therapy
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Uterine Neoplasms / metabolism*
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Uterine Neoplasms / pathology
Substances
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Antineoplastic Agents
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Receptors, Estrogen
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Receptors, Progesterone
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Tamoxifen
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Estradiol
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Medroxyprogesterone Acetate
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Medroxyprogesterone