Abstract
A rapid, convenient, precise HPLC method was developed for the simultaneous determination of aripiprazole and its active metabolite dehydroaripiprazole in blood serum. The separation was carried out by RP HPLC on Symmetry C₁₈ column (150 x 4.6 mm; 5 μm). The mobile phase was composed of acetonitrile: water (30 : 70, v/v), pH 3.0 adjusted with o-phosphoric acid. The detection was monitored at 220 nm.
MeSH terms
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Acetonitriles / chemistry
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Activation, Metabolic
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Antipsychotic Agents / blood*
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Aripiprazole / blood*
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Buffers
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Chemistry, Pharmaceutical
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Chromatography, High Pressure Liquid*
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Chromatography, Reverse-Phase
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Drug Compounding
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Drug Monitoring / methods*
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Humans
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Hydrogen-Ion Concentration
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Phosphoric Acids / chemistry
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Piperazines / blood*
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Quinolones / blood*
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Schizophrenia / blood
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Schizophrenia / diagnosis
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Schizophrenia / drug therapy*
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Solvents / chemistry
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Water / chemistry
Substances
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Acetonitriles
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Antipsychotic Agents
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Buffers
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Phosphoric Acids
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Piperazines
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Quinolones
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Solvents
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Water
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dehydroaripiprazole
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Aripiprazole
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phosphoric acid
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acetonitrile