[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

Miguel A Cortés González; Patrik Nordeman; Antonio Bermejo Gómez; Denise N Meyer; Gunnar Antoni; Magnus Schou; Kálmán J Szabó

doi:10.1039/c8cc00526e

[¹⁸F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

Chem Commun (Camb). 2018 Apr 24;54(34):4286-4289. doi: 10.1039/c8cc00526e.

Authors

Miguel A Cortés González¹, Patrik Nordeman, Antonio Bermejo Gómez, Denise N Meyer, Gunnar Antoni, Magnus Schou, Kálmán J Szabó

Affiliation

¹ Department of Organic Chemistry, Stockholm University, SE-106 91, Sweden. [email protected].

PMID: 29632936
DOI: 10.1039/c8cc00526e

Abstract

Operationally simple radiosynthesis and purification of [18F]fluoro-benziodoxole was developed starting from a cyclotron produced [18F]F- precursor, [18F]TBAF, and tosyl-benziodoxole. The synthetic utility of [18F]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50-90%) and high molar activity (up to 396 GBq μmol-1).