Nitrate-promoted Selective C-H Fluorination of Benzamides and Benzeneacetamides

Org Lett. 2018 Apr 20;20(8):2445-2448. doi: 10.1021/acs.orglett.8b00793. Epub 2018 Apr 10.

Abstract

A versatile and site-selective nitrate-promoted C-H bond fluorination using various weak coordinating amides as intrinsic directing groups was developed. Diverse tertiary and secondary amides underwent selective aromatic C-H bond fluorination, which features broad substrate scope, good regioselectivity, and mild conditions. Moreover, the late-stage C-H bond fluorination of the challenging benzeneacetamides via distal directing was reported for the first time.

Publication types

  • Research Support, Non-U.S. Gov't