Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Shigemitsu Horie; Hayato Nishida; Toshihiko Sakurai; Osamu Ichiyanagi; Tomoyuki Kato; Makoto Yagi; Takanobu Kabasawa; Teigo Asai; Norihiko Tsuchiya

doi:10.1111/iju.13567

Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Int J Urol. 2018 Jun;25(6):627-629. doi: 10.1111/iju.13567. Epub 2018 Apr 12.

Authors

Shigemitsu Horie¹, Hayato Nishida¹, Toshihiko Sakurai¹, Osamu Ichiyanagi¹, Tomoyuki Kato¹, Makoto Yagi², Takanobu Kabasawa³, Teigo Asai⁴, Norihiko Tsuchiya¹

Affiliations

¹ Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
² Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
³ Department of Pathological Diagnostics, Faculty of Medicine, Yamagata University, Yamagata, Japan.
⁴ Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

PMID: 29651797
DOI: 10.1111/iju.13567

Abstract

Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

Keywords: intestinal edema; liposarcoma; mucosal crystallization; pazopanib; tyrosine kinase inhibitor.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Agents / adverse effects*
Edema / chemically induced*
Edema / diagnostic imaging
Edema / pathology
Endoscopy, Gastrointestinal
Humans
Indazoles
Intestinal Diseases / chemically induced*
Intestinal Diseases / diagnostic imaging
Intestinal Diseases / pathology
Intestinal Mucosa / diagnostic imaging
Intestinal Mucosa / drug effects
Intestinal Mucosa / pathology
Kidney Neoplasms / drug therapy
Liposarcoma / drug therapy
Male
Neoplasm Recurrence, Local / drug therapy*
Pyrimidines / adverse effects*
Retroperitoneal Neoplasms / drug therapy
Sulfonamides / adverse effects*
Tomography, X-Ray Computed

Substances

Antineoplastic Agents
Indazoles
Pyrimidines
Sulfonamides
pazopanib

Supplementary concepts

Retroperitoneal liposarcoma