Ectopic Lck expression in CLL demarcates intratumoral subpopulations with aberrant B-cell receptor signaling

Blood Adv. 2018 Apr 24;2(8):877-882. doi: 10.1182/bloodadvances.2017015321.

Authors

Efthymia Theofani^{1

2}, Spyridon Alexis², Paul Costeas³, Christos Andriopoulos², Georgia Feleskoura², Panagiotis Zikos⁴, Anthi Aktypi⁵, Alexandros Spyridonidis², Konstantina Nika¹

Affiliations

¹ Department of Biochemistry, School of Medicine, University of Patras, Patras, Greece.
² Bone Marrow Transplantation Unit and FACS Laboratory, University Hospital of Patras, Patras, Greece.
³ The Center for the Study of Haematological Malignancies, Nicosia, Cyprus.
⁴ General Hospital of Patras "Agios Andreas," Patras, Greece; and.
⁵ Specialist Physician Haematologist, Patras, Greece.

Abstract

Ectopic Lck expression signifies interpatient and intratumoral heterogeneity in CLL.
Lck expression identifies CLL subpopulations with aberrant BCR signaling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD5 Antigens
Genetic Heterogeneity*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism*
Receptors, Antigen, B-Cell / metabolism*
Signal Transduction

Substances

CD5 Antigens
Receptors, Antigen, B-Cell
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)