Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment

Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(3):454-457.e1. doi: 10.1016/j.jcmgh.2017.11.006. eCollection 2018 Mar.

Luc Gailhouste¹, Lee Chuen Liew^{1

2}, Ken Yasukawa^{1

3}, Keitaro Hagiwara¹, Norihiko Iwazaki⁴, Yasuhiro Yamada⁴, Izuho Hatada⁵, Takahiro Ochiya¹

¹ Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
² Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
³ Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
⁴ Drug Metabolism and Pharmacokinetics Research Laboratories, Mitsubishi Tanabe Pharma Corporation, Saitama, Japan.
⁵ Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

No abstract available

Keywords: 5-AZA, 5-azacytidine; CYP, cytochrome P; Dex, dexamethasone; PB, phenobarbital sodium.