Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation

Pavel Uhrin; Dongdong Wang; Andrei Mocan; Birgit Waltenberger; Johannes M Breuss; Devesh Tewari; Judit Mihaly-Bison; Łukasz Huminiecki; Rafał R Starzyński; Nikolay T Tzvetkov; Jarosław Horbańczuk; Atanas G Atanasov

doi:10.1016/j.biotechadv.2018.04.002

Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation

Biotechnol Adv. 2018 Nov 1;36(6):1608-1621. doi: 10.1016/j.biotechadv.2018.04.002. Epub 2018 Apr 17.

Affiliations

¹ Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna 1090, Austria. Electronic address: [email protected].
² Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Magdalenka 05552, Poland; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna 1090, Austria; Institute of Clinical Chemistry, University Hospital Zurich, Wagistrasse 14, Schlieren 8952, Switzerland.
³ Department of Pharmaceutical Botany, "Iuliu Hatieganu" University of Medicine and Pharmacy, Strada Victor Babeş 8, Cluj-Napoca 400012, Romania; ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Calea Mănăştur 3-5, Cluj-Napoca 400372, Romania.
⁴ Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, Innsbruck 6020, Austria.
⁵ Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna 1090, Austria.
⁶ Department of Pharmaceutical Sciences, Faculty of Technology, Kumaun University, Nainital, Uttarakhand 263136, India.
⁷ Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Magdalenka 05552, Poland.
⁸ Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53121, Germany; NTZ Lab Ltd., Krasno Selo 198, Sofia 1618, Bulgaria.
⁹ Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Magdalenka 05552, Poland; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna 1090, Austria. Electronic address: [email protected].

PMID: 29678389
DOI: 10.1016/j.biotechadv.2018.04.002

Abstract

Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indirubin-3'-monoxime, resveratrol, hyperoside, plumericin, pelargonidin, zerumbone and apamin. Moreover, taxol and rapamycin, the most prominent compounds applied in drug-eluting stents to counteract restenosis, are natural products. Numerous studies show that natural products have proven to yield effective inhibitors of vascular smooth muscle cell proliferation and ongoing research effort might result in the discovery of further clinically relevant compounds.

Keywords: Atherosclerosis; Drug-discovery; Molecular target; Natural products; Restenosis; Signaling pathway; Vascular smooth muscle cell proliferation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biological Products / pharmacology*
Cell Proliferation / drug effects*
Cells, Cultured
Drug Discovery*
Humans
Muscle, Smooth, Vascular / cytology*
Signal Transduction
Vascular Diseases

Substances

Biological Products