Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology

Melissa H Bloodworth; Mark Rusznak; Connor C Pfister; Jian Zhang; Lisa Bastarache; Sandra Alvarez Calvillo; James D Chappell; Kelli L Boyd; Shinji Toki; Dawn C Newcomb; Matthew T Stier; Weisong Zhou; Kasia Goleniewska; Martin L Moore; Tina V Hartert; Kevin D Niswender; R Stokes Peebles Jr

doi:10.1016/j.jaci.2018.01.053

Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology

J Allergy Clin Immunol. 2018 Aug;142(2):683-687.e12. doi: 10.1016/j.jaci.2018.01.053. Epub 2018 Apr 17.

Authors

Melissa H Bloodworth¹, Mark Rusznak², Connor C Pfister², Jian Zhang², Lisa Bastarache³, Sandra Alvarez Calvillo⁴, James D Chappell⁴, Kelli L Boyd¹, Shinji Toki², Dawn C Newcomb⁵, Matthew T Stier¹, Weisong Zhou², Kasia Goleniewska², Martin L Moore⁶, Tina V Hartert², Kevin D Niswender⁷, R Stokes Peebles Jr⁸

Affiliations

¹ Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn.
² Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
³ Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tenn.
⁴ Division of Infectious Disease, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn.
⁵ Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
⁶ Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
⁷ Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
⁸ Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address: [email protected].

Abstract

GLP-1R signaling, an emerging anti-inflammatory therapeutic 59 target, 60 attenuated type 2-associated immunopathology in mice infected with a strain of RSV that was 61 isolated from a hospitalized infant with severe lower respiratory tract infection and bronchiolitis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Glucagon-Like Peptide-1 Receptor / agonists
Glucagon-Like Peptide-1 Receptor / metabolism*
Humans
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / therapeutic use*
Immunity, Innate
Infant
Interleukin-13 / metabolism
Liraglutide / pharmacology
Liraglutide / therapeutic use*
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Respiratory Syncytial Virus Infections / immunology*
Respiratory Syncytial Viruses / physiology*
Signal Transduction
Th2 Cells / immunology*
Viral Load

Substances

Glp1r protein, mouse
Glucagon-Like Peptide-1 Receptor
Hypoglycemic Agents
Interleukin-13
Liraglutide

Abstract

Publication types

MeSH terms

Substances

Grants and funding