Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable blaDHA-1-carrying plasmid by an ST23 strain

Yingzhou Xie; Lijun Tian; Gang Li; Hongping Qu; Jingyong Sun; Wei Liang; Xiaobin Li; Xiaoli Wang; Zixin Deng; Jialin Liu; Hong-Yu Ou

doi:10.1080/21505594.2018.1456229

Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable bla_DHA-1-carrying plasmid by an ST23 strain

Virulence. 2018 Dec 31;9(1):838-844. doi: 10.1080/21505594.2018.1456229.

Authors

Yingzhou Xie¹, Lijun Tian², Gang Li³, Hongping Qu², Jingyong Sun⁴, Wei Liang⁵, Xiaobin Li¹, Xiaoli Wang², Zixin Deng¹, Jialin Liu², Hong-Yu Ou^{1

6}

Affiliations

¹ a State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University , Shanghai , China.
² b Department of Critical Care Medicine , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
³ c Department of Laboratory Medicine , Jinshan Hospital Fudan University , Shanghai , China.
⁴ d Department of Clinical Microbiology , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
⁵ e Department of Laboratory Medicine , the Second People's Hospital of Lianyungang , Jiangsu , China.
⁶ f Shanghai Key Laboratory of Veterinary Biotechnology , School of Life Sciences & Biotechnology, Shanghai Jiao Tong University , Shanghai , China.

No abstract available

Keywords: blaDHA-1; comparative genomic analysis; conjugation transfer; hypervirulent Klebsiella pneumoniae; multidrug resistant plasmid.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animal Structures
Animals
Anti-Bacterial Agents / pharmacology*
Bacterial Load
Cephalosporins / pharmacology*
Disease Models, Animal
Evolution, Molecular
Gene Transfer, Horizontal*
Humans
Klebsiella Infections / microbiology
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / genetics*
Klebsiella pneumoniae / pathogenicity
Lepidoptera
Microbial Sensitivity Tests
Plasmids / analysis*
Survival Analysis
Virulence
beta-Lactam Resistance*
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
Cephalosporins
beta-Lactamases

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China [31670074 and 21661140002], the National Key R&D Program of China [2017YFC1600105], Shanghai Science & Technology Specific Projects [124119a6100], and the Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University [YG2015MS59].