Improved Pathological Examination of Tumors with 3D Light-Sheet Microscopy

Per Uhlén; Nobuyuki Tanaka

doi:10.1016/j.trecan.2018.03.003

Improved Pathological Examination of Tumors with 3D Light-Sheet Microscopy

Trends Cancer. 2018 May;4(5):337-341. doi: 10.1016/j.trecan.2018.03.003. Epub 2018 Mar 27.

Authors

Per Uhlén¹, Nobuyuki Tanaka²

Affiliations

¹ Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden. Electronic address: [email protected].
² Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden; Department of Urology, Keio University School of Medicine, 160-8582 Tokyo, Japan. Electronic address: [email protected].

PMID: 29709257
DOI: 10.1016/j.trecan.2018.03.003

Abstract

Light-sheet microscopy offers new possibilities to efficiently visualize large tissue samples in three dimensions. Volumetric 3D imaging can uncover detailed information about the inner landscape of tumors, which can improve cancer diagnosis and therapy. This Forum article highlights the advantages of using light-sheet microscopy for pathological examinations of intact tumor specimens.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Microscopy / methods*
Neoplasms / pathology*