Protein Folding: A Perspective from Theory and Experiment

Christopher M Dobson; Andrej Šali; Martin Karplus

doi:10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H

Protein Folding: A Perspective from Theory and Experiment

Angew Chem Int Ed Engl. 1998 Apr 20;37(7):868-893. doi: 10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H.

Authors

Christopher M Dobson¹, Andrej Šali², Martin Karplus³

Affiliations

¹ Oxford Centre for Molecular Sciences, New Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QT (UK), Fax: (+44) 1-865-275-921.
² The Rockefeller University, New York, NY (USA).
³ Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 (USA), Fax: (+1) 617-496-3204 (and) Laboratoire de Chimie Biophysique, Institut Le Bel, Universite Louis Pasteur, F-67000 Strasbourg (France), Fax: (+33) 388-60-83-63.

PMID: 29711488
DOI: 10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H

Abstract

The mechanism of protein folding (represented schematically below) is one of the most fascinating problems in the field of chemical reactions. This review presents the progess made recently in understanding key elements of this reaction and describes a solution to the often quoted Levinthal Paradox.

Keywords: Kinetics; Molecular dynamics; Protein folding; Proteins; Structure elucidation.

Publication types

Review