Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants

Martin Kantlehner; Dirk Finsinger; Jörg Meyer; Patricia Schaffner; Alfred Jonczyk; Beate Diefenbach; Berthold Nies; Horst Kessler

doi:10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F

Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants

Angew Chem Int Ed Engl. 1999 Feb 15;38(4):560-562. doi: 10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F.

Authors

Martin Kantlehner¹, Dirk Finsinger¹, Jörg Meyer², Patricia Schaffner², Alfred Jonczyk³, Beate Diefenbach³, Berthold Nies², Horst Kessler¹

Affiliations

¹ Institut für Organische Chemie und Biochemie der Technischen Universität München, Lichtenbergstrasse 4, D-85747 Garching (Germany), Fax: (+49) 89-2891-3210.
² Merck Biomaterial GmbH, Forschung, Darmstadt (Germany).
³ Merck KGaA, Präklinische Forschung, Darmstadt (Germany).

PMID: 29711769
DOI: 10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F

Abstract

Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.

Keywords: Bioorganic chemistry; Integrins; Materials science; Peptides; Surface chemistry.