Color Indicators of Molecular Chirality Based on Doped Liquid Crystals

Richard A van Delden; Ben L Feringa

doi:10.1002/1521-3773(20010903)40:17<3198::AID-ANIE3198>3.0.CO;2-I

Color Indicators of Molecular Chirality Based on Doped Liquid Crystals

Angew Chem Int Ed Engl. 2001 Sep 3;40(17):3198-3200. doi: 10.1002/1521-3773(20010903)40:17<3198::AID-ANIE3198>3.0.CO;2-I.

Authors

Richard A van Delden¹, Ben L Feringa¹

Affiliation

¹ Department of Organic and Molecular Inorganic Chemistry Stratingh Institute, University of Groningen Nijenborgh 4, 9747 AG Groningen (The Netherlands) Fax: (+31) 50-363-4296.

PMID: 29712043
DOI: 10.1002/1521-3773(20010903)40:17<3198::AID-ANIE3198>3.0.CO;2-I

Abstract

A simple color test for enantiomeric excess requires no chiral auxiliaries and only microgram quantities of chiral products. The method is based on a chirality-dependent color generation in doped LC films on formation of an imine or ester from an amine and carbaldehyde or alcohol and acid chloride, respectively, and will enable the rapid screening of libraries of nonracemic compounds.

Keywords: asymmetric catalysis; chirality; combinatorial chemistry; enantioselectivity; liquid crystals.