Differences in symptoms and presentation delay times in myocardial infarction patients with and without diabetes: A cross-sectional study in Pakistan

Indian Heart J. 2018 Mar-Apr;70(2):241-245. doi: 10.1016/j.ihj.2017.07.013. Epub 2017 Jul 27.

Abstract

Objective: A short pre-hospital delay, from the onset of symptoms to rapid initiation of reperfusion therapy, is a crucial factor in determining prognosis of myocardial infarction (MI). The purpose of this study was to evaluate symptoms and presentation delay times in MI patients with and without diabetes.

Methods: This cross-sectional study was conducted in 3 tertiary care hospitals of Pakistan over a period of 6 months. The study sample consisted of 280 consenting individuals diagnosed with ST-elevation MI (STEMI) or Non-ST elevation MI (NSTEMI), out of which 130 were diabetic and 150 were non-diabetic. Data was collected using a standardized questionnaire, investigating MI symptoms along with causes and duration of pre-hospital delay within 72hours of admission.

Results: No significant difference was found in the intensity of chest pain between diabetics and non-diabetics. Atypical symptoms of MI such as anxiety (p<0.001), cold sweats (p=0.034) and epigastric pain (p=0.017) were more frequently reported in diabetics. MI patients with diabetes had a significantly longer presentation delay time with 75% of the patients presenting after elapse of 3h. Only a few patients reported to the hospital within an hour of onset of symptoms (n=23, 8.2%), out of which majority were non-diabetics (n=18). A majority of patients (n=146, 52%) in both groups did not use emergency medical services.

Conclusion: This study provides an incentive for further research, aiming to reduce pre hospital delay along with investigating the effectiveness of emergency medical services.

Keywords: Decision making; Diabetes mellitus; Myocardial infarction; Pakistan; Symptoms.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Diabetes Mellitus / epidemiology*
  • Electrocardiography
  • Emergency Medical Services / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Incidence
  • Male
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / surgery
  • Myocardial Revascularization*
  • Pakistan / epidemiology
  • Retrospective Studies
  • Surveys and Questionnaires
  • Survival Rate / trends
  • Time Factors
  • Time-to-Treatment / trends*