First report of the isolation of blaIMI-1-producing colistin-heteroresistant Enterobacter cloacae in Japan, September 2016

Norihito Tarumoto; Masahiro Kodana; Noriyuki Watanabe; Jun Sakai; Kazuo Imai; Toshiyuki Yamaguchi; Yoshitada Taji; Yasuhiro Ebihara; Takashi Murakami; Takuya Maeda; Kotaro Mitsutake; Shigefumi Maesaki

doi:10.1016/j.jiac.2018.04.004

First report of the isolation of bla_IMI-1-producing colistin-heteroresistant Enterobacter cloacae in Japan, September 2016

J Infect Chemother. 2018 Nov;24(11):941-943. doi: 10.1016/j.jiac.2018.04.004. Epub 2018 Apr 30.

Affiliations

¹ Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan; Center for Clinical Infectious Diseases and Research, Saitama Medical University, Saitama, Japan.
² Clinical Laboratory Medicine, Saitama Medical University Hospital, Saitama, Japan.
³ Clinical Laboratory, International Medical Center, Saitama Medical University, Saitama, Japan.
⁴ Department of Laboratory Medicine, International Medical Center, Saitama Medical University, Saitama, Japan.
⁵ Center for Clinical Infectious Diseases and Research, Saitama Medical University, Saitama, Japan; Department of Microbiology, Saitama Medical University, Saitama, Japan.
⁶ Center for Clinical Infectious Diseases and Research, Saitama Medical University, Saitama, Japan; Department of Microbiology, Saitama Medical University, Saitama, Japan. Electronic address: [email protected].
⁷ Center for Clinical Infectious Diseases and Research, Saitama Medical University, Saitama, Japan; Department of Infectious Diseases and Infection Control, International Medical Center, Saitama Medical University, Saitama, Japan.

PMID: 29716812
DOI: 10.1016/j.jiac.2018.04.004

Abstract

The isolation of a carbapenem-resistant Enterobacter cloacae strain harboring the IMI-1 variant of bla_IMI-1 carbapenemase points to the worldwide emergence of multidrug resistant bacteria as a potential source of health care infections. In this report, we describe the first isolation of E. cloacae with bla_IMI-1 carbapenemase isolated from a Japanese patient in September 2016. The isolate was resistant to carbapenems, levofloxacin, and aminoglycosides, and heteroresistant to colistin but sensitive to fourth-generation cephalosporins. All microbiology laboratories worldwide should be made aware of these bla_IMI-1-producing subtypes with unusual antibiotic susceptibility profiles.

Keywords: Carbapenemase; Colistin; Enterobacter cloacae; Heteroresistant; bla(IMI-1).

Publication types

Case Reports

MeSH terms

Aminoglycosides / pharmacology
Aminoglycosides / therapeutic use
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Bacterial Proteins / genetics
Carbapenems / pharmacology
Carbapenems / therapeutic use
Cephalosporins / pharmacology
Cephalosporins / therapeutic use
Colistin / pharmacology*
Colistin / therapeutic use
Drug Resistance, Multiple, Bacterial / genetics*
Enterobacter cloacae / genetics
Enterobacter cloacae / isolation & purification*
Enterobacteriaceae Infections / drug therapy*
Enterobacteriaceae Infections / microbiology
Humans
Japan
Levofloxacin / pharmacology
Levofloxacin / therapeutic use
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

Aminoglycosides
Anti-Bacterial Agents
Bacterial Proteins
Carbapenems
Cephalosporins
Levofloxacin
beta-Lactamases
carbapenemase
Colistin