Gamma delta T cell expansion in Whipple's disease with muscular granulomatous vasculitis

Infection. 2018 Aug;46(4):573-576. doi: 10.1007/s15010-018-1143-3. Epub 2018 May 3.

Abstract

Whipple's disease usually presents as chronic joint pain followed by digestive manifestations. However, many different presentations have been described in the literature. We report here the first proven case of muscular vasculitis related to Whipple's disease, associated with an expansion of circulating activated γδ T lymphocytes.

Keywords: Gamma delta T cells; Granulomatosis with polyangeitis; Tropheryma whipplei; Vasculitis; Whipple’s disease.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Biomarkers
  • Granulomatosis with Polyangiitis / complications*
  • Humans
  • Lymphocyte Count*
  • Male
  • Middle Aged
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • Symptom Assessment
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism*
  • Treatment Outcome
  • Whipple Disease / complications*
  • Whipple Disease / diagnosis
  • Whipple Disease / drug therapy
  • Whipple Disease / immunology*

Substances

  • Anti-Bacterial Agents
  • Biomarkers
  • Receptors, Antigen, T-Cell, gamma-delta