As more and more studies suggest that type 2 diabetes mellitus (T2DM) is closely related to male hypogonadism, people begin to pay more attention to the role of testosterone in the development of T2DM and the effect and safety of testosterone supplementary therapy. There is some controversy in randomized controlled studies and meta-analyses about the effects of testosterone supplementation on the blood glucose level, androgen deficiency symptoms, and cardiovascular diseases. This review focuses on the diagnosis of hypogonadism in T2DM males, differences in the therapeutic effects and safety of testosterone replacement among different studies, and rational use of testosterone supplementation for T2DM patients.
随着越来越多的研究表明2型糖尿病与男性性腺功能减退密切相关，人们开始关注睾酮在2型糖尿病的发生、发展中所起的角色和作用，以及睾酮补充治疗的有效性和安全性。在大量随机对照研究及荟萃分析中，关于睾酮补充治疗对2型糖尿病男性患者的血糖控制、胰岛素抵抗、雄激素缺乏相关症状以及心血管疾病发病率的影响有所争议。本综述将通过对2型糖尿病男性患者性腺功能减退的诊断、各研究之间睾酮补充治疗的疗效差异及其安全性的分析，对睾酮补充治疗的合理用药展开探讨。.
Keywords: hypogonadism; testosterone supplementary therapy; type-2 diabetes mellitus.