HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia

Mandy Johnstone; Rana Fetit

doi:10.1016/j.stem.2018.04.008

HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia

Cell Stem Cell. 2018 May 3;22(5):609-611. doi: 10.1016/j.stem.2018.04.008.

Authors

Mandy Johnstone¹, Rana Fetit²

Affiliations

¹ Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Electronic address: [email protected].
² Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Abstract

In this issue of Cell Stem Cell, Sarkar et al. (2018) describe an efficient method for the generation of human hippocampal pyramidal neurons from stem cells. They developed a compelling in vitro model that recapitulates synaptic connectivity within the hippocampus and showed that cells derived from patients with schizophrenia exhibit abnormal electrical activity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Hippocampus
Humans
Neurons
Pluripotent Stem Cells*
Pyramidal Cells
Schizophrenia*

Abstract

Publication types

MeSH terms

Grants and funding