Nucleophilic ring opening reactions of aziridines

Mol Divers. 2018 May;22(2):447-501. doi: 10.1007/s11030-018-9829-0. Epub 2018 May 4.

Abstract

Aziridine ring opening reactions have gained tremendous importance in the synthesis of nitrogen containing biologically active molecules. During recent years, a great effort has been put forward by scientists toward unique bond construction methodologies via ring opening of aziridines. In this regard, a wide range of chiral metal- and organo-catalyzed desymmetrization reactions of aziridines have been reported with carbon, sulfur, oxygen, nitrogen, halogen, and other nucleophiles. In this review, an outline of methodologies adopted by a number of scientists during 2013-2017 for aziridine ring opening reactions as well as their synthetic applications is described.

Keywords: Aziridine; Biologically active compounds; Enantioselective synthesis; Methodology development; Ring opening reactions.

Publication types

  • Review

MeSH terms

  • Aziridines / chemistry*
  • Stereoisomerism

Substances

  • Aziridines