Endometriosis is a common benign disease of Gynecology, which often causes symptoms of dysmenorrhea, pelvic pain and infertility. In this paper, we analyzed the effect of laparoscopy combined with mifepristone in the treatment of endometriosis. By observing the clinical efficacy and side effects of small dose mifepristone, we explored the feasibility of small dose mifepristone in the treatment of recurrent endometriosis. The results showed that the clinical symptoms of small dose mifepristone group and danazol group were improved to varying degrees. The improvement rate of mifepristone group was 96.7% for dysmenorrhea and 61.1% for non menstrual lower abdominal pain, respectively. In conclusion, small dose mifepristone is an effective treatment for recurrent endometriosis with high remission and good curative effect.