Abstract
An extract of Petradoria pumila from the Natural Products Discovery Institute was found to have moderate antiplasmodial activity, with an IC50 value between 5 and 10 μg/mL. The four new diterpenoids petradoriolides A-D (1-4), the new benzotropolone petradoriolone (5), and the two known lignans 6 and 7 were isolated after bioassay-directed fractionation. The structures and stereochemistries of the new compounds were determined by interpretation of NMR spectroscopy, mass spectrometry, and ECD spectra. Among these compounds, petradoriolide C (3) displayed the most potent antiplasmodial activity, with an IC50 value of 7.3 μM.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antimalarials / chemistry*
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Antimalarials / pharmacology
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Asteraceae / chemistry*
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Biflavonoids / chemistry*
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Biflavonoids / pharmacology
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Catechin / analogs & derivatives*
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Catechin / chemistry
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Catechin / pharmacology
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Diterpenes / chemistry*
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Diterpenes / pharmacology
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Lignans / chemistry
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy / methods
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plasmodium falciparum / drug effects
Substances
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Antimalarials
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Biflavonoids
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Diterpenes
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Lignans
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Plant Extracts
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benzotropolone
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Catechin