Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation

Zhengao Wang; Jinquan Zeng; Guoxin Tan; Jingwen Liao; Lei Zhou; Junqi Chen; Peng Yu; Qiyou Wang; Chengyun Ning

doi:10.1016/j.bioactmat.2017.05.006

Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation

Bioact Mater. 2017 May 26;3(1):74-79. doi: 10.1016/j.bioactmat.2017.05.006. eCollection 2018 Mar.

Authors

Zhengao Wang^{1

2}, Jinquan Zeng³, Guoxin Tan⁴, Jingwen Liao⁵, Lei Zhou^{1

2}, Junqi Chen^{1

2}, Peng Yu^{1

2}, Qiyou Wang⁶, Chengyun Ning^{1

2}

Affiliations

¹ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
² Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006, China.
³ Guangzhou Tieyi Middle School, Guangzhou 510660, China.
⁴ Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
⁵ Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 510006, China.
⁶ Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

Abstract

To improve the osteointegration property of biomedical titanium, nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole. The highly binding affinity of Ca²⁺ to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions. The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid. The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant.

Keywords: Catechol; Hydroxyapatite; Nanowires; Polypyrrole; Titanium.