Abstract
Aim:
To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo.
Materials & methods:
The efficacy of ozenoxacin formulations was compared with vehicle control, mupirocin and retapamulin ointments in a mouse model.
Results:
The most effective concentrations of ozenoxacin for reducing S. aureus counts after dermal application were 1 and 2%. Direct comparison of two batches of 1% ozenoxacin ointment and cream with 1% retapamulin and 2% mupirocin ointments in the mouse model showed superior efficacy of ozenoxacin.
Conclusion:
1% ozenoxacin ointment and cream were the most effective formulations in significantly reducing bacterial load in S. aureus dermally infected mice.
Keywords:
Staphylococcus aureus; animal models; dermal infection; impetigo; ozenoxacin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Aminopyridines / administration & dosage*
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Aminopyridines / pharmacology
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Aminopyridines / therapeutic use
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Animals
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Animals, Outbred Strains
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Bridged Bicyclo Compounds, Heterocyclic / administration & dosage
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
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Disease Models, Animal
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Diterpenes
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Dose-Response Relationship, Drug
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Humans
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Impetigo / drug therapy*
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Mice
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Mupirocin / administration & dosage
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Mupirocin / pharmacology
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Mupirocin / therapeutic use
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Ointments
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Quinolones / administration & dosage*
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Quinolones / pharmacology
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Quinolones / therapeutic use
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Skin Cream / administration & dosage
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Skin Cream / pharmacology
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Skin Cream / therapeutic use
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Staphylococcus aureus / drug effects*
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Treatment Outcome
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Wound Infection / drug therapy*
Substances
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Aminopyridines
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Anti-Bacterial Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Diterpenes
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Ointments
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Quinolones
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retapamulin
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Mupirocin
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ozenoxacin