[Tea consumption and the risk of lung cancer in Chinese males: a prospective cohort study]

Zhonghua Yu Fang Yi Xue Za Zhi. 2018 May 6;52(5):511-516. doi: 10.3760/cma.j.issn.0253-9624.2018.05.010.
[Article in Chinese]

Abstract

Objective: To investigate the association between tea consumption and lung cancer risk in Chinese males. Methods: Tea consumption and incident lung cancer cases were collected on a biennial basis among males in Kailuan Cohort during 2006-2015. Up to 31st December 2015, a total of 103 010 male candidates from the Chinese Kailuan Male Cohort Study were enrolled in the present study. Cox proportional hazards regression model was used to evaluate the association between tea consumption and risk of lung cancer in males. Results: The age of male candidates was (51.3±13.4)years old. There were 828 810.74 person-years of follow-up and 8.91 years of median follow-up period. During the follow-up, 964 lung cancer cases were identified. In male, the rate of never cosumers, tea drinkers (<4/week) and tea drinkers (≥4/week) were 58.17%(n=59 926), 24.04%(n=24 765) and 17.78%(n=18 319), respectively. After adjustment for potential confounding factors, HR (95%CI) of lung cancer for subjects with tea drinkers (<4/week) and tea drinkers (≥4/week) were 0.80 (0.63-1.02) and 1.02 (0.80-1.30), respectively, as compared with never cosumers. The results showed no significant association with lung cancer. Stratification analysis and sensitivity analysis showed no significant changes. Conclusion: Our study has not found that tea consumption is significantly associated with the risk of male lung cancer.

目的: 研究我国男性饮茶与肺癌发病风险之间的关联。 方法: 于2006年以开滦集团≥18岁整体在职及离退休男性职工为研究对象,收集人群资料及饮茶相关信息,建立动态队列,每两年进行一次随访,收集对象肺癌发病结局信息。截至2015年12月31日,共有103 010名男性进入研究。以不饮茶人群为对照组,利用Cox比例风险回归模型分析饮茶状况与男性肺癌发病风险的关联。 结果: 调查对象男性年龄为(51.3±13.4)岁,共随访828 810.74人年,中位随访时间为8.91年,收集到肺癌新发病例964例。其中,有59 926名(58.17%)调查对象不饮茶,24 765名(24.04%)每周饮茶<4次、18 319名(17.78%)每周饮茶≥4次。调整年龄、教育程度、经济收入、吸烟情况、饮酒情况、粉尘暴露、BMI、饮茶类型、肿瘤家族史等潜在的混杂因素后,与不饮茶对象相比,每周饮茶<4次组(HR=0.80,95%CI: 0.63~1.02)和≥4次组(HR=1.02,95%CI: 0.80~1.30)与男性肺癌发病差异无统计学意义。根据吸烟状况等进行分层分析及敏感性分析结果未发生明显变化。 结论: 尚未发现饮茶与男性肺癌发病风险存在相关性。.

Keywords: Cohort study; Lung neoplasms; Male; Prospective study; Tea.

MeSH terms

  • Adult
  • China / epidemiology
  • Cohort Studies
  • Female
  • Humans
  • Lung Neoplasms / epidemiology*
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Risk
  • Risk Factors
  • Tea

Substances

  • Tea