Abstract
The presence of the adenovirus E1A-like activity in embryonal carcinoma stem cells has been reported. We now show that preimplantation stage mouse embryonic cells allow transcription of the E1A-dependent E2A gene when infected with E1A-deleted mutant dl312, indicating the presence of the E1A-like activity in morulae and blastocysts. Moreover, such activity seems to decrease or disappear at about the time of implantation.
MeSH terms
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Adenovirus Early Proteins
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Animals
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Antigens, Viral, Tumor / genetics*
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Blastocyst / cytology
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Blastocyst / microbiology*
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Cleavage Stage, Ovum / microbiology*
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Female
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Fluorescent Antibody Technique
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Mice
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Mice, Inbred ICR
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Morula / cytology
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Morula / microbiology*
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Oncogene Proteins, Viral / analysis
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Oncogene Proteins, Viral / genetics*
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Superovulation
Substances
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Adenovirus Early Proteins
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Antigens, Viral, Tumor
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Oncogene Proteins, Viral