Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1

Endocrinology. 2018 Jul 1;159(7):2545-2553. doi: 10.1210/en.2018-00371.

Abstract

Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adipose tissue depots, beige adipocytes are also thermogenic; however, beige adipocytes possess unique, distinguishing characteristics in their developmental regulation and biological function. This review highlights recent advances in our understanding of beige adipocytes, focusing on the diverse roles of beige fat in the regulation of energy homeostasis that are independent of the canonical thermogenic pathway via uncoupling protein 1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue, Beige / metabolism*
  • Adipose Tissue, Brown / metabolism
  • Animals
  • Energy Metabolism / genetics
  • Energy Metabolism / physiology
  • Homeostasis / genetics
  • Homeostasis / physiology
  • Humans
  • Uncoupling Protein 1 / metabolism*

Substances

  • Uncoupling Protein 1