Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota

Manoj Kumar; Tarun Mathur; Vattan Joshi; Dilip J Upadhyay; Shin-Ichi Inoue; Nobuhisa Masuda

doi:10.1016/j.anaerobe.2018.04.017

Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota

Anaerobe. 2018 Jun:51:120-123. doi: 10.1016/j.anaerobe.2018.04.017. Epub 2018 May 2.

Authors

Manoj Kumar¹, Tarun Mathur¹, Vattan Joshi¹, Dilip J Upadhyay¹, Shin-Ichi Inoue², Nobuhisa Masuda³

Affiliations

¹ Department of Microbiology, Daiichi Sankyo India Pharma Private Limited, Gurgaon, Haryana, India.
² Daiichi Sankyo Co., Ltd., Tokyo, Japan.
³ Department of Microbiology, Daiichi Sankyo India Pharma Private Limited, Gurgaon, Haryana, India. Electronic address: [email protected].

PMID: 29758524
DOI: 10.1016/j.anaerobe.2018.04.017

Abstract

DS-2969b, a novel GyrB inhibitor, transiently and reversibly altered the counts of limited intestinal microbiota at around 10 μg/g of faecal levels in rats and monkeys. Considering the high activity of DS-2969b against Clostridium difficile, 10 μg/g of faecal levels would be sufficient for clearing C. difficile from the intestine.

Keywords: Clostridium difficile; Microbiota.

MeSH terms

Animals
Bacterial Load
Clostridioides difficile / drug effects
DNA Gyrase / metabolism*
Feces / microbiology
Gastrointestinal Microbiome / drug effects*
Haplorhini
Rats
Topoisomerase II Inhibitors / administration & dosage*

Substances

Topoisomerase II Inhibitors
DNA Gyrase