Aztreonam-Avibactam Combination Restores Susceptibility of Aztreonam in Dual-Carbapenemase-Producing Enterobacteriaceae

Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00414-18. doi: 10.1128/AAC.00414-18. Print 2018 Aug.
No abstract available

Keywords: aztreonam-avibactam; carbapenem-resistant Enterobacteriaceae; carbapenemase; meropenem-vaborbactam; multidrug-resistant bacteria.

Publication types

  • Letter

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Azabicyclo Compounds / pharmacology*
  • Aztreonam / pharmacology*
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Carbapenem-Resistant Enterobacteriaceae / drug effects*
  • Carbapenem-Resistant Enterobacteriaceae / enzymology
  • Carbapenem-Resistant Enterobacteriaceae / genetics
  • Citrobacter freundii / drug effects
  • Citrobacter freundii / enzymology
  • Citrobacter freundii / genetics
  • Drug Combinations
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / enzymology
  • Enterobacter cloacae / genetics
  • Enterobacteriaceae Infections / drug therapy*
  • Enterobacteriaceae Infections / epidemiology
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Escherichia coli / genetics
  • Gene Expression
  • Humans
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / genetics
  • Microbial Sensitivity Tests
  • Singapore / epidemiology
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Bacterial Proteins
  • Drug Combinations
  • Isoenzymes
  • avibactam
  • beta-Lactamases
  • carbapenemase
  • Aztreonam