Abstract
Intraperitoneal injection of 5 mg/kg of tetrahydro-9-amino-acridine (THA) in rats 1 h before intrastriatal injection of 50-150 nmol of quinolinic acid potentiated the local neurotoxicity as indicated by measurements of striatal levels of glutamate decarboxylase and choline acetyltransferase. A larger dose (10 mg/kg) THA had no significant effect. The results are discussed in terms of THA's binding to various elements of the NMDA/sigma receptor complex and reported data on such binding are confirmed.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aminoacridines / pharmacology*
-
Animals
-
Choline O-Acetyltransferase / metabolism
-
Corpus Striatum / drug effects
-
Corpus Striatum / metabolism*
-
Dose-Response Relationship, Drug
-
Drug Interactions
-
Glutamate Decarboxylase / metabolism
-
Male
-
Neurotoxins / pharmacology*
-
Pyridines / toxicity*
-
Quinolinic Acid
-
Quinolinic Acids / toxicity*
-
Rats
-
Rats, Inbred Strains
-
Tacrine / pharmacology*
Substances
-
Aminoacridines
-
Neurotoxins
-
Pyridines
-
Quinolinic Acids
-
Tacrine
-
Choline O-Acetyltransferase
-
Glutamate Decarboxylase
-
Quinolinic Acid