Musculoskeletal Manifestations of Amyloidosis: A Focused Review

Thomas X Nguyen; Abbas Naqvi; Terry L Thompson; Robert H Wilson

Musculoskeletal Manifestations of Amyloidosis: A Focused Review

J Surg Orthop Adv. 2018 Spring;27(1):1-5.

Authors

Thomas X Nguyen¹, Abbas Naqvi², Terry L Thompson², Robert H Wilson²

Affiliations

¹ Department of Orthopaedic Surgery, Howard University Hospital, Washington, D.C. [email protected].
² Department of Orthopaedic Surgery, Howard University Hospital, Washington, D.C.

PMID: 29762107

Abstract

Amyloidosis is a poorly understood condition that can wreak havoc on numerous systems within the human body. In addition, this disease can present in multiple forms which each have their own unique physiology and subsequent effects. However, while the literature on the etiology and effect of amyloidosis on various organ systems is numerous, few have highlighted the musculoskeletal manifestations of this devastating disease. This review focuses on the recent research on amyloid deposition in the musculoskeletal system. Additionally, risk factors, classification, differential diagnoses, indications for biopsy, and manifestations of amyloidosis in the musculoskeletal system as well as in other tissues are discussed. Furthermore, the surgical and nonsurgical approaches to treatment are covered. (Journal of Surgical Orthopaedic Advances 27(1):1-5, 2018).

Publication types

Review

MeSH terms

Amyloid Neuropathies, Familial
Amyloidosis / complications
Amyloidosis / diagnosis
Amyloidosis / pathology
Amyloidosis / physiopathology*
Arthritis, Rheumatoid / diagnosis
Arthroplasty
Biopsy
Bone Neoplasms / diagnosis
Bone and Bones
Cartilage, Articular
Chondrosarcoma / diagnosis
Conservative Treatment
Cyclophosphamide / therapeutic use
Diagnosis, Differential
Humans
Immunoglobulin Light-chain Amyloidosis
Immunosuppressive Agents / therapeutic use
Joint Diseases / diagnosis
Joint Diseases / etiology
Joint Diseases / pathology
Joint Diseases / physiopathology
Ligaments
Liver Transplantation
Melphalan / therapeutic use
Muscular Diseases / diagnosis
Muscular Diseases / etiology
Muscular Diseases / pathology
Muscular Diseases / physiopathology
Musculoskeletal Diseases / diagnosis
Musculoskeletal Diseases / etiology
Musculoskeletal Diseases / pathology
Musculoskeletal Diseases / physiopathology*
Orthopedic Procedures
Prednisone / therapeutic use
Risk Factors
Serum Amyloid A Protein
Sex Factors
Spondylarthropathies / diagnosis
Synovial Membrane
beta 2-Microglobulin

Substances

Immunosuppressive Agents
Serum Amyloid A Protein
beta 2-Microglobulin
Cyclophosphamide
Melphalan
Prednisone

Supplementary concepts

Amyloidosis, Hereditary, Transthyretin-Related