[The relationship between IL-4 and trace elements in patients with allergic rhinitis of hui and han populations in Ningxia]

Objective: To examine the relationship between trace elements and IL-4 in patients with allergic rhinitis(AR).Method:According to the inclusion and exclusion criteria, a total of 260 cases in AR group(130 hui cases, 130 han cases),and 260 cases in normal control group(130 hui cases, 130 han cases) were recruited in this study. The concentrations of IL-4 were detected by enzyme linked immunosorbent assay(ELISA), the contents of Zn, Mn, Ni, Se and Fe were determined by inductively coupled plasma atomic emission spectrometry(ICP-AES), and the correlation between the trace elements and IL-4 were also analyzed.Result:IL-4 levels in serum of both hui and han AR patients were higher than those in control group(P <0.05). Contents of serum Zn and Se in hui AR patients were lower than those in control group(P <0.05), Ni content was higher than that in control group(P <0.05);Zn level in serum of han AR cases was lower than that in control group,Ni content was higher than that in control group (P <0.05).The serum IL-4 level in AR group was positively correlated with Ni(P <0.01,r=0.671), and negatively correlated with Zn(P <0.01, r=-0.819).Conclusion:We demonstrated that there are significant correlations between IL-4 and Zn,Ni in the serum of patients with AR in Ningxia hui and han population. It indicates that trace elements are involved in the occurrence and development of AR, and may as a therauptic target of AR.